Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
نویسندگان
چکیده
منابع مشابه
Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
Vascular endothelial growth factors (VEGFs) and their receptors play crucial roles in the formation of blood and lymphatic vessels during embryogenesis, and also under pathologic conditions in the adult. Despite intensive efforts over the last decades to elucidate the precise functions of VEGFs, transcriptional responses to VEGF receptor stimulation are still not fully characterized. To investi...
متن کاملVEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells Short title for running head: VEGFR-3+ lymphatic/vascular endothelial precursors
Human CD133(AC133)+CD34+ stem and progenitor cells derived from fetal liver and bone marrow, and blood incorporate a functional population of circulating endothelial precursor cells. Vascular endothelial growth factor receptor 3 (VEGFR-3) regulates cardiovascular development, and physiological and pathological lymphangiogenesis and angiogenesis. However, the origin of VEGFR-3+ endothelial cells...
متن کاملCD34+VEGFR-3+ progenitor cells have a potential to differentiate towards lymphatic endothelial cells
Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization. However, it is poorly understood whether EPCs contribute to lymphangiogenesis. Here, we assessed differentiation of a novel population of EPCs towards lymphatic endothelial cells and their lymphatic formation. CD34(+) VEGFR-3(+) EPCs were isolated from mononuclear cells of human cord blood by fluorescenc...
متن کاملDissecting VEGFR-2 and VEGFR-3 function: VEGFR-3 mediates lymphangiogenic signals
............................................................................................................................ 6 REVIEW OF THE LITERATURE...................................................................................... 7 1. THE BLOOD VASCULAR SYSTEM........................................................................... 7 Development of the blood vessels......................
متن کاملDifferential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Blood vessels are required for a tumor to grow and functional lymphatic vessels are required for it to disseminate to lymph nodes. In an attempt to eradicate both the primary tumor and its lymphatic metastasis, we targeted both blood and lymphatic vessels using two different tyrosine kinase inhibitors (TKIs): cediranib and vandetanib, which block vascular endothelial growth factor receptor (VEG...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Data
سال: 2017
ISSN: 2052-4463
DOI: 10.1038/sdata.2017.106